Each age has evolved its signature empirical methods for refining their craft. The 21st century is still in search of a signature paradigm.  But surely it will involve networks for physical transport of tangible goods (logistics), speed of light transit of intellectual goods (communication networks), and virtual neighborhoods of like minded individuals (social networks).  This talk reviews the network paradigms and their consequences for all of us that will evolve over the next two decades. Their impact will range from the quest for immortality and freedom from illness, to frictionless economies that promise welfare and productivity to all.